People born to older fathers have higher risk of developing non-Hodgkin’s lymphoma   7 comments

I’m reading a great article in the American Journal of Epidemiology (May issue). According to a new study published by City of Hope, evidence is mounting that a the risk of developing non-Hodgkin lymphoma is much higher in kids who have older fathers. This one-of-a-kind study examined the relationship between parents’ ages and their now-adult children’s chances of facing cancers that effect the blood and immune system.

The research focused on about 111,000 women, 819 of which had been diagnosed with some kind of hematological malignancy. The research revealed that the participants who had fathers who were older than 40 years old when they were born had a 59% higher risk of developing non-Hodgkin’s lymphoma when compared to women who were born to fathers younger than 25 years old.

This is interesting to me because it seems more and more these days I’m reading research stories that prove that the ticking biological clock of both women men is associated with a more health issues in children.

The researchers of this study think that the male biological clock might relate to mutations that can accumulate in a man’s reproductive cells over the course of a lifetime. “These cells divide more rapidly than a woman’s reproductive cells. More divisions lead to more chances for abnormalities to arise. The study reveals that older parental age also appears to be associated with longer length of offspring’s telomeres, the end caps on chromosomes, which might be linked to non-Hodgkin’s lymphoma risk,” the study says.

The doctor who ran the study, City of Hope research fellow Yani Lu, said, “As a man, you may think, ‘I can have a baby at 50 or 60 and live long enough to see him go through college. But there may be other risks for your child down the line, and you may want to be conscious of those risks.”

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Posted June 24, 2010 by lymphomactivist in Uncategorized

7 responses to “People born to older fathers have higher risk of developing non-Hodgkin’s lymphoma

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  1. My sister was just diagnosed with non-Hodgkin’s lymphoma and our dad was 55 when he had her. This study directly relates to her. Wow. Great post, thanks for posting this.

  2. Interesting. When was she diagnosed? I hope treatment is going well.

  3. She was diagnosed last month and is doing well so far. Thanks for your concern; that’s sweet of you. Looking forward to reading more of your posts about causes of the disease.

  4. Great, Jenny, I’m glad to hear it. I’m now following your blog as well–funny stuff! It’s nice that you have such a positive look on the situation and can add humor to the discussion of such a heart-breaking subject.

  5. Interesting that someone whose sister was just diagnosed stumbled upon your blog. Very interesting post!

  6. Does it say anything about whether it affects men or women more?

    Matthew Donnelly
  7. I don’t remember reading whether it was more prevalent in males or females. I think it was the same for both.

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